Differential pulmonary immunopathology of domestic sheep (Ovis aries) and bighorn sheep (Ovis canadensis) with Mycoplasma ovipneumoniae infection: A retrospective study

Mycoplasma ovipneumoniae is a respiratory pathogen that impacts domestic sheep (Ovis aries; DS) and bighorn canadensis; BHS). BHS are reported to be more susceptible than DS developing polymicrobial pneumonia associated with M. infection. Using formalin-fixed paraffin-embedded tissues, we performed retrospective study investigating the pulmonary immune response of infected exhibited robust well-organized BALT formation as compared BHS. Digital analysis immunohistochemical chromogen deposition in lung tissue was used quantitate T cell marker CD3, B markers CD20 CD79a, macrophage CD163 Iba1, cytokine IL-17. A significant interaction species infection status identified for CD163, had greater increase bronchiolar CD3 alveolar infection, DS. an lymph (BALT) IL-17 while these remained similar regardless status. epithelium bronchi bronchioles comparatively decreased increased These data begin define interspecies differential provide first investigations epithelium-associated ovine.